Polycations sensitize enteric bacteria to antibiotics

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Polycations sensitize enteric bacteria to antibiotics.

Polymyxin B nonapeptide, a polymyxin B derivative which lacks the fatty acyl part and the bactericidal activity of polymyxin, was shown to sensitize smooth encapsulated Escherichia coli (O18:K1) and smooth Salmonella typhimurium to hydrophobic antibiotics (novobiocin, fusidic acid, erythromycin, clindamycin, nafcillin, and cloxacillin). The polymyxin B nonapeptide-treated bacteria were as sensi...

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ژورنال

عنوان ژورنال: Antimicrobial Agents and Chemotherapy

سال: 1983

ISSN: 0066-4804,1098-6596

DOI: 10.1128/aac.24.1.107